BDBM326196 US10273223, Compound D-95::US9637472, Compound D-95

SMILES: Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)C2=CCN(CCO)CC2)c(=O)[nH]1

InChI Key: InChIKey=MYPJDOZCQPNBAT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 326196   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM326196 (US10273223, Compound D-95 | US9637472, Compound D-...) Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)C2=CCN(CCO)CC2)c(=O)[nH]1 |t:27| Show InChI InChI=1S/C28H35N5O3/c1-18-13-19(2)31-28(36)24(18)16-29-27(35)23-14-21(20-7-9-32(10-8-20)11-12-34)15-26-25(23)17-30-33(26)22-5-3-4-6-22/h7,13-15,17,22,34H,3-6,8-12,16H2,1-2H3,(H,29,35)(H,31,36)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
IRBM/Merck					Assay Description eneral Procedure for Wild-Type PRC2 Enzyme Assay on Oligonucleosome Substrate. The assays was performed in a buffer consisting of 20 mM bicine (pH=7....				J Med Chem 51: 2350-3 (2008) BindingDB Entry DOI: 10.7270/Q28P62V9
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM326196 (US10273223, Compound D-95 | US9637472, Compound D-...) Show SMILES Cc1cc(C)c(CNC(=O)c2cc(cc3n(ncc23)C2CCCC2)C2=CCN(CCO)CC2)c(=O)[nH]1 |t:27| Show InChI InChI=1S/C28H35N5O3/c1-18-13-19(2)31-28(36)24(18)16-29-27(35)23-14-21(20-7-9-32(10-8-20)11-12-34)15-26-25(23)17-30-33(26)22-5-3-4-6-22/h7,13-15,17,22,34H,3-6,8-12,16H2,1-2H3,(H,29,35)(H,31,36)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<300	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description Recombinant PRC2 Enzymes. Human PRC2 enzymes were purified as 4-component enzyme complexes co-expressed in Spodoptera frugiperda (sf9) cells using a ...				US Patent US9637472 (2017) BindingDB Entry DOI: 10.7270/Q2X0693B
					More data for this Ligand-Target Pair