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SMILES: C[C@H]1CC[C@H](Cn2ccc3nc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)CC1

InChI Key:

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   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 326315   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
E3 ubiquitin-protein ligase Mdm2 [17-125]


(Homo sapiens (Human))		BDBM326315
PNG
(3-{4-(5-chloropyridin-3- yl)-5-[(trans-4- methylcy...)
Show SMILES C[C@H]1CC[C@H](Cn2ccc3nc(nc(-c4cncc(Cl)c4)c23)-c2noc(=O)[nH]2)CC1 |r,wU:4.4,wD:1.0,(6.59,-5.23,;5.25,-4.46,;5.25,-2.92,;3.92,-2.15,;2.58,-2.92,;1.25,-2.15,;1.25,-.61,;2.16,.64,;1.25,1.88,;-.21,1.41,;-1.55,2.18,;-2.88,1.41,;-2.88,-.13,;-1.55,-.9,;-1.55,-2.44,;-.21,-3.21,;-.21,-4.75,;-1.55,-5.52,;-2.88,-4.75,;-4.22,-5.52,;-2.88,-3.21,;-.21,-.13,;-4.22,2.18,;-5.68,1.7,;-6.59,2.95,;-5.68,4.19,;-6.45,5.52,;-4.22,3.72,;2.58,-4.46,;3.92,-5.23,)|
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 57n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...

US Patent US9637493 (2017)


BindingDB Entry DOI: 10.7270/Q28917Z1
More data for this
Ligand-Target Pair