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SMILES: CC(C)Cc1cn(C[C@H]2CC[C@H](C)CC2)c2c(nc(nc12)-c1noc(=O)[nH]1)-c1cncc(Cl)c1

InChI Key:

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 326324   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
E3 ubiquitin-protein ligase Mdm2 [17-125]


(Homo sapiens (Human))		BDBM326324
PNG
(3-[4-(5-chloropyridin-3- yl)-5-[(trans-4- methylcy...)
Show SMILES CC(C)Cc1cn(C[C@H]2CC[C@H](C)CC2)c2c(nc(nc12)-c1noc(=O)[nH]1)-c1cncc(Cl)c1 |r,wU:8.7,wD:11.11,(3.54,5.25,;3.14,3.77,;4.23,2.68,;1.65,3.37,;1.25,1.88,;2.16,.64,;1.25,-.61,;1.25,-2.15,;2.58,-2.92,;3.92,-2.15,;5.25,-2.92,;5.25,-4.46,;6.59,-5.23,;3.92,-5.23,;2.58,-4.46,;-.21,-.13,;-1.55,-.9,;-2.88,-.13,;-2.88,1.41,;-1.55,2.18,;-.21,1.41,;-4.22,2.18,;-5.68,1.7,;-6.59,2.95,;-5.68,4.19,;-6.45,5.52,;-4.22,3.72,;-1.55,-2.44,;-.21,-3.21,;-.21,-4.75,;-1.55,-5.52,;-2.88,-4.75,;-4.22,-5.52,;-2.88,-3.21,)|
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 35n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...

US Patent US9637493 (2017)


BindingDB Entry DOI: 10.7270/Q28917Z1
More data for this
Ligand-Target Pair