BDBM327448 1-(4-amino-5-fluoro-2-methoxyphenyl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one::US9663465, 5
SMILES: COc1cc(N)c(F)cc1C(=O)CCC1CCN(CC2CCCCC2)CC1
InChI Key: InChIKey=PXUUPGSNIMQISW-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serotonin (5-HT) receptor (Homo sapiens (Human)) | BDBM327448 (1-(4-amino-5-fluoro-2-methoxyphenyl)-3-[1-(cyclohe...) | UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITE DE CAEN US Patent | Assay Description Prior to these competition studies, a series of saturation curves were performed in order to check whether the pharmacological parameters Kd, Bmax an... | US Patent US9663465 (2017) BindingDB Entry DOI: 10.7270/Q23J3G2W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acetylcholinesterase (Homo sapiens (Human)) | BDBM327448 (1-(4-amino-5-fluoro-2-methoxyphenyl)-3-[1-(cyclohe...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
UNIVERSITE DE CAEN US Patent | Assay Description Acetylcholinesterase extracted from human erythrocytes (buffered aqueous solution, ≧500 units/mg, Sigma Aldrich) is diluted in a 20 mM HEPES bu... | US Patent US9663465 (2017) BindingDB Entry DOI: 10.7270/Q23J3G2W | |||||||||||
More data for this Ligand-Target Pair |