BDBM327842 2-((R)-2-methyl-4-((R)-phenyl(4-(2-phenylethynyl)phenyl)methyl)piperazin-1-yl)acetic acid::US9663476, Compound 55A

SMILES: C[C@@H]1CN(CCN1CC(O)=O)[C@H](c1ccccc1)c1ccc(cc1)C#Cc1ccccc1

InChI Key: InChIKey=IUPFIUUFWNDGBI-SKCUWOTOSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 327842   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycine transporter 1 (Homo sapiens (Human))	BDBM327842 (2-((R)-2-methyl-4-((R)-phenyl(4-(2-phenylethynyl)p...) Show SMILES C[C@@H]1CN(CCN1CC(O)=O)[C@H](c1ccccc1)c1ccc(cc1)C#Cc1ccccc1 Show InChI InChI=1S/C28H28N2O2/c1-22-20-30(19-18-29(22)21-27(31)32)28(25-10-6-3-7-11-25)26-16-14-24(15-17-26)13-12-23-8-4-2-5-9-23/h2-11,14-17,22,28H,18-21H2,1H3,(H,31,32)/t22-,28-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description This cell-based assay measures the ability of test compounds to inhibit the uptake of glycine by the glycine transporter type 1. Human placental chor...				US Patent US9663476 (2017) BindingDB Entry DOI: 10.7270/Q2KK9DWS
					More data for this Ligand-Target Pair