null

SMILES: Fc1ccc(cc1)C(=O)C1(F)CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1

InChI Key: InChIKey=WQUGCKCCOOBUNT-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 327927   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327927 (N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4-fluo...) Show SMILES Fc1ccc(cc1)C(=O)C1(F)CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1 Show InChI InChI=1S/C32H31F2N5O3/c33-26-8-5-24(6-9-26)29(40)32(34)13-17-39(18-14-32)31(42)25-7-10-28(36-20-25)30(41)37-27-11-15-38(16-12-27)21-23-3-1-22(19-35)2-4-23/h1-10,20,27H,11-18,21H2,(H,37,41)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<500	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US9663496 (2017) BindingDB Entry DOI: 10.7270/Q26975P8
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM327927 (N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4-fluo...) Show SMILES Fc1ccc(cc1)C(=O)C1(F)CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1 Show InChI InChI=1S/C32H31F2N5O3/c33-26-8-5-24(6-9-26)29(40)32(34)13-17-39(18-14-32)31(42)25-7-10-28(36-20-25)30(41)37-27-11-15-38(16-12-27)21-23-3-1-22(19-35)2-4-23/h1-10,20,27H,11-18,21H2,(H,37,41)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmc.2022.116951 BindingDB Entry DOI: 10.7270/Q2HX1HM7
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM327927 (N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4-fluo...) Show SMILES Fc1ccc(cc1)C(=O)C1(F)CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1 Show InChI InChI=1S/C32H31F2N5O3/c33-26-8-5-24(6-9-26)29(40)32(34)13-17-39(18-14-32)31(42)25-7-10-28(36-20-25)30(41)37-27-11-15-38(16-12-27)21-23-3-1-22(19-35)2-4-23/h1-10,20,27H,11-18,21H2,(H,37,41)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmc.2022.116951 BindingDB Entry DOI: 10.7270/Q2HX1HM7
					More data for this Ligand-Target Pair
5'-AMP-activated protein kinase catalytic subunit alpha-2 (Homo sapiens (Human))	BDBM327927 (N-(1-(4- cyanobenzyl)piperidin-4- yl)-5-(4-(4-fluo...) Show SMILES Fc1ccc(cc1)C(=O)C1(F)CCN(CC1)C(=O)c1ccc(nc1)C(=O)NC1CCN(Cc2ccc(cc2)C#N)CC1 Show InChI InChI=1S/C32H31F2N5O3/c33-26-8-5-24(6-9-26)29(40)32(34)13-17-39(18-14-32)31(42)25-7-10-28(36-20-25)30(41)37-27-11-15-38(16-12-27)21-23-3-1-22(19-35)2-4-23/h1-10,20,27H,11-18,21H2,(H,37,41)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<500	n/a	n/a	n/a	n/a
Rigel Pharmaceuticals, Inc. US Patent					Assay Description Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...				US Patent US10377742 (2019) BindingDB Entry DOI: 10.7270/Q2RV0R22
					More data for this Ligand-Target Pair