BDBM329200 4-(5-chloro-6-(cyclobutyloxy)-3-pyridinyl)-2-fluoro-5-::4-(5-chloro-6-(cyclobutyloxy)-3-pyridinyl)-2-fluoro-5-methoxy-N-(methylsulfonyl)benzamide::US9663508, Example 702
SMILES: COc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(OC2CCC2)c(Cl)c1
InChI Key: InChIKey=DGHAHFNJROJTII-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM329200 (4-(5-chloro-6-(cyclobutyloxy)-3-pyridinyl)-2-fluor...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 68.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. US Patent | Assay Description HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy... | US Patent US9663508 (2017) BindingDB Entry DOI: 10.7270/Q2JM2CRZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM329200 (4-(5-chloro-6-(cyclobutyloxy)-3-pyridinyl)-2-fluor...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc Curated by ChEMBL | Assay Description Inhibition of human Nav1.5 expressed in HEK293 cells incubated for 3 to 5 mins at -50 mV holding potential by electrophysiology assay | J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM329200 (4-(5-chloro-6-(cyclobutyloxy)-3-pyridinyl)-2-fluor...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc Curated by ChEMBL | Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assay | J Med Chem 59: 7818-39 (2016) Article DOI: 10.1021/acs.jmedchem.6b00425 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM329200 (4-(5-chloro-6-(cyclobutyloxy)-3-pyridinyl)-2-fluor...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >4.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. US Patent | Assay Description 293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste... | US Patent US9663508 (2017) BindingDB Entry DOI: 10.7270/Q2JM2CRZ | |||||||||||
More data for this Ligand-Target Pair |