BDBM329280 (R)-4-(2-fluoro-4-methoxyphenyl)-7-[1-(2-methylpyrimidin-5-yl)propan-2(R or S)-yl]quinoline-2-carboxamide::US9663506, Example 8-10
SMILES: COC(=O)c1cc(-c2ccc(OC)cc2F)c2ccc(cc2n1)[C@H](C)Cc1cnc(C)nc1
InChI Key: InChIKey=KNOJZZCRWJYAID-OAHLLOKOSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM329280 ((R)-4-(2-fluoro-4-methoxyphenyl)-7-[1-(2-methylpyr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR... | US Patent US9663506 (2017) BindingDB Entry DOI: 10.7270/Q2PC34H4 | |||||||||||
More data for this Ligand-Target Pair |