BDBM329551 1-(4-(4-(((1R,2R)-2-(6,7- dihydro-5H- cyclopenta[b]pyridin-2- yl)cyclopropyl)methoxy)- 2-methylpyrimidin-5-yl)- 1-methyl-1H-pyrazol-3- yl)ethanol(enantiomer A, R or S)::US9663513, 164::US9663513, 165::US9663513, 166::US9663513, 167

SMILES: CC(O)c1nn(C)cc1-c1cnc(C)nc1OC[C@@H]1C[C@H]1c1ccc2CCCc2n1

InChI Key: InChIKey=AKELEHXXIQFOQF-ZMKYACIDSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 329551   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM329551 (1-(4-(4-(((1R,2R)-2-(6,7- dihydro-5H- cyclopenta[b...) Show SMILES CC(O)c1nn(C)cc1-c1cnc(C)nc1OC[C@@H]1C[C@H]1c1ccc2CCCc2n1 |r| Show InChI InChI=1S/C23H27N5O2/c1-13(29)22-19(11-28(3)27-22)18-10-24-14(2)25-23(18)30-12-16-9-17(16)21-8-7-15-5-4-6-20(15)26-21/h7-8,10-11,13,16-17,29H,4-6,9,12H2,1-3H3/t13?,16-,17+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...				US Patent US9663513 (2017) BindingDB Entry DOI: 10.7270/Q25D8TXC
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM329551 (1-(4-(4-(((1R,2R)-2-(6,7- dihydro-5H- cyclopenta[b...) Show SMILES CC(O)c1nn(C)cc1-c1cnc(C)nc1OC[C@@H]1C[C@H]1c1ccc2CCCc2n1 |r| Show InChI InChI=1S/C23H27N5O2/c1-13(29)22-19(11-28(3)27-22)18-10-24-14(2)25-23(18)30-12-16-9-17(16)21-8-7-15-5-4-6-20(15)26-21/h7-8,10-11,13,16-17,29H,4-6,9,12H2,1-3H3/t13?,16-,17+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...				US Patent US9663513 (2017) BindingDB Entry DOI: 10.7270/Q25D8TXC
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM329551 (1-(4-(4-(((1R,2R)-2-(6,7- dihydro-5H- cyclopenta[b...) Show SMILES CC(O)c1nn(C)cc1-c1cnc(C)nc1OC[C@@H]1C[C@H]1c1ccc2CCCc2n1 |r| Show InChI InChI=1S/C23H27N5O2/c1-13(29)22-19(11-28(3)27-22)18-10-24-14(2)25-23(18)30-12-16-9-17(16)21-8-7-15-5-4-6-20(15)26-21/h7-8,10-11,13,16-17,29H,4-6,9,12H2,1-3H3/t13?,16-,17+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.44	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...				US Patent US9663513 (2017) BindingDB Entry DOI: 10.7270/Q25D8TXC
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM329551 (1-(4-(4-(((1R,2R)-2-(6,7- dihydro-5H- cyclopenta[b...) Show SMILES CC(O)c1nn(C)cc1-c1cnc(C)nc1OC[C@@H]1C[C@H]1c1ccc2CCCc2n1 |r| Show InChI InChI=1S/C23H27N5O2/c1-13(29)22-19(11-28(3)27-22)18-10-24-14(2)25-23(18)30-12-16-9-17(16)21-8-7-15-5-4-6-20(15)26-21/h7-8,10-11,13,16-17,29H,4-6,9,12H2,1-3H3/t13?,16-,17+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	8.11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...				US Patent US9663513 (2017) BindingDB Entry DOI: 10.7270/Q25D8TXC
					More data for this Ligand-Target Pair