BDBM331840 (R)-7-[4-(3-cyano-2-hydroxypropyl)oxy-2-methoxyphenyl]-8-(5-fluoro-2-methyl-phenoxymethyl)-1,3,3-trimethyl-3,4-dihydro-1H-quinoxalin-2-one::US10189796, Compound 5-1::US10435379, Compound 5-1
SMILES: COc1cc(OC[C@H](O)CC#N)ccc1-c1ccc2NC(C)(C)C(=O)N(C)c2c1COc1cc(F)ccc1C
InChI Key: InChIKey=PRPUCYPOQXAQPA-HXUWFJFHSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Interleukin-6 (Homo sapiens (Human)) | BDBM331840 ((R)-7-[4-(3-cyano-2-hydroxypropyl)oxy-2-methoxyphe...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
SANTEN PHARMACEUTICAL CO., LTD. US Patent | Assay Description 1) The subcultured HCE-T was recovered and the cells were seeded at 2.0×104 cells/0.1 mL/well in a 96-well flat bottom culture plate.2) After culturi... | US Patent US10435379 (2019) BindingDB Entry DOI: 10.7270/Q2X350TP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interleukin-6 (Homo sapiens (Human)) | BDBM331840 ((R)-7-[4-(3-cyano-2-hydroxypropyl)oxy-2-methoxyphe...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
SANTEN PHARMACEUTICAL CO., LTD. US Patent | Assay Description o evaluate the action of the present compounds as a GR agonist, IL-6 production inhibitory action in human corneal epithelial cell line after LPS sti... | US Patent US10189796 (2019) BindingDB Entry DOI: 10.7270/Q21G0PBH | |||||||||||
More data for this Ligand-Target Pair |