BDBM332040 (E)-N'-(3,5-di-tert-butyl-2- hydroxybenzal)-2-{N-{2- [N-(3-methoxybenzyl)-N- methylamino]ethyl}N- methylamino}acethydrazide::US10196346, Example 22
SMILES: COc1cccc(CN(C)CCN(C)CC(=O)N\N=C\c2cc(cc(c2O)C(C)(C)C)C(C)(C)C)c1
InChI Key: InChIKey=IWVMQDIPYSKLNK-UXHLAJHPSA-N
Data: 1 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human)) | BDBM332040 ((E)-N'-(3,5-di-tert-butyl-2- hydroxybenzal)-2-{N-{...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 2.77E+3 | n/a | n/a | n/a | n/a |
Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China US Patent | Assay Description The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut... | US Patent US10196346 (2019) BindingDB Entry DOI: 10.7270/Q2VQ34SQ | |||||||||||
More data for this Ligand-Target Pair |