BDBM332055 US10189854, Compound 3::[1-[5-(1-Fluorophenyl)-pyrimidin-2-yl]-spiro[1,2-dihydro-indole-3,1'-cyclopropane]-6-yl]-pyrrolidin-1-yl-methanone

SMILES: Fc1ccccc1-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCCC1

InChI Key: InChIKey=KPPBEFQPVQNBHW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 332055   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM332055 (US10189854, Compound 3 | [1-[5-(1-Fluorophenyl)-py...) Show SMILES Fc1ccccc1-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N1CCCC1 Show InChI InChI=1S/C25H23FN4O/c26-21-6-2-1-5-19(21)18-14-27-24(28-15-18)30-16-25(9-10-25)20-8-7-17(13-22(20)30)23(31)29-11-3-4-12-29/h1-2,5-8,13-15H,3-4,9-12,16H2	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
GRUENENTHAL GMBH US Patent					Assay Description The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...				US Patent US10189854 (2019) BindingDB Entry DOI: 10.7270/Q2N87CW4
					More data for this Ligand-Target Pair