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SMILES: CN1CCN(CC1)C(=O)c1ccc2c(c1)N(CC21CC1)c1ncc(cn1)-c1ccccc1F

InChI Key: InChIKey=GBGDXJTWUNHMSA-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 332106   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B


(Homo sapiens (Human))		BDBM332106
PNG
(US10189854, Compound 60 | [1-[5-(2-Fluorophenyl)-p...)
Show SMILES CN1CCN(CC1)C(=O)c1ccc2c(c1)N(CC21CC1)c1ncc(cn1)-c1ccccc1F
Show InChI InChI=1S/C26H26FN5O/c1-30-10-12-31(13-11-30)24(33)18-6-7-21-23(14-18)32(17-26(21)8-9-26)25-28-15-19(16-29-25)20-4-2-3-5-22(20)27/h2-7,14-16H,8-13,17H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
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PC cid
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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



GRUENENTHAL GMBH

US Patent


Assay Description
The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...

US Patent US10189854 (2019)


BindingDB Entry DOI: 10.7270/Q2N87CW4
More data for this
Ligand-Target Pair