BDBM332580 (2E)-1-{2-[(2E)-3-(3,4-dichlorophenyl)prop-2-enoyl]-2,7-diazaspiro[3.5]non-7-yl}-3-(3,4-dichlorophenyl)prop-2-en-1-one::US10196369, Compound C35
SMILES: Clc1ccc(\C=C\C(=O)N2CC3(C2)CCN(CC3)C(=O)\C=C\c2ccc(Cl)c(Cl)c2)cc1Cl
InChI Key: InChIKey=YWMLTXBSPOLXIK-FCXRPNKRSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G-protein coupled receptor 183 (Homo sapiens (Human)) | BDBM332580 ((2E)-1-{2-[(2E)-3-(3,4-dichlorophenyl)prop-2-enoyl...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a | n/a |
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent | Assay Description The test compounds that demonstrated a corrected % activity of >=50% were defined as inhibitors of the reaction. The experimental values were normali... | US Patent US10196369 (2019) BindingDB Entry DOI: 10.7270/Q2BR8V88 | |||||||||||
More data for this Ligand-Target Pair |