BDBM332724 2-(4-(5-dimethylcarbamoylpyridin-2-yl)piperazin-1-yl)-1H-benzimidazole-4-carboxamide::US10196381, Compound (15)

SMILES: CN(C)C(=O)c1ccc(nc1)N1CCN(CC1)c1nc2c(cccc2[nH]1)C(N)=O

InChI Key: InChIKey=MWEGMNAKNHSTDE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 332724   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM332724 (2-(4-(5-dimethylcarbamoylpyridin-2-yl)piperazin-1-...) Show SMILES CN(C)C(=O)c1ccc(nc1)N1CCN(CC1)c1nc2c(cccc2[nH]1)C(N)=O Show InChI InChI=1S/C20H23N7O2/c1-25(2)19(29)13-6-7-16(22-12-13)26-8-10-27(11-9-26)20-23-15-5-3-4-14(18(21)28)17(15)24-20/h3-7,12H,8-11H2,1-2H3,(H2,21,28)(H,23,24)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HUILUN LIFE SCIENCE &TECHNOLOGY CO., LTD US Patent					Assay Description 1. 50 μl of 1×PARP buffer per well was added to infiltrate the histone, and the plate was incubated for 30 min at room temperature. Then the 1×P...				US Patent US10196381 (2019) BindingDB Entry DOI: 10.7270/Q2TT4T17
					More data for this Ligand-Target Pair