BDBM332734 6-fluoro-2-(4-(5-methylcarbamoylpyridin-2-yl)piperazin-1-yl)-1H-benzimidazole-4-carboxamide::US10196381, Compound (24)

SMILES: CNC(=O)c1ccc(nc1)N1CCN(CC1)c1nc2c(cc(F)cc2[nH]1)C(N)=O

InChI Key: InChIKey=KBJNQEXQZCCCOC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 332734   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM332734 (6-fluoro-2-(4-(5-methylcarbamoylpyridin-2-yl)piper...) Show SMILES CNC(=O)c1ccc(nc1)N1CCN(CC1)c1nc2c(cc(F)cc2[nH]1)C(N)=O Show InChI InChI=1S/C19H20FN7O2/c1-22-18(29)11-2-3-15(23-10-11)26-4-6-27(7-5-26)19-24-14-9-12(20)8-13(17(21)28)16(14)25-19/h2-3,8-10H,4-7H2,1H3,(H2,21,28)(H,22,29)(H,24,25)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HUILUN LIFE SCIENCE &TECHNOLOGY CO., LTD US Patent					Assay Description 1. 50 μl of 1×PARP buffer per well was added to infiltrate the histone, and the plate was incubated for 30 min at room temperature. Then the 1×P...				US Patent US10196381 (2019) BindingDB Entry DOI: 10.7270/Q2TT4T17
					More data for this Ligand-Target Pair