BDBM332739 6-fluoro-2-(4-(5-(pyrrolin-1-acyl)pyrazin-2-yl)piperazin-1-yl)-1H-benzimidazole-4-carboxamide::US10196381, Compound (29)

SMILES: NC(=O)c1cc(F)cc2[nH]c(nc12)N1CCN(CC1)c1cnc(cn1)C(=O)N1CCCC1

InChI Key: InChIKey=IXPBUTAULXTNHL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 332739   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM332739 (6-fluoro-2-(4-(5-(pyrrolin-1-acyl)pyrazin-2-yl)pip...) Show SMILES NC(=O)c1cc(F)cc2[nH]c(nc12)N1CCN(CC1)c1cnc(cn1)C(=O)N1CCCC1 Show InChI InChI=1S/C21H23FN8O2/c22-13-9-14(19(23)31)18-15(10-13)26-21(27-18)30-7-5-28(6-8-30)17-12-24-16(11-25-17)20(32)29-3-1-2-4-29/h9-12H,1-8H2,(H2,23,31)(H,26,27)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
SHANGHAI HUILUN LIFE SCIENCE &TECHNOLOGY CO., LTD US Patent					Assay Description 1. 50 μl of 1×PARP buffer per well was added to infiltrate the histone, and the plate was incubated for 30 min at room temperature. Then the 1×P...				US Patent US10196381 (2019) BindingDB Entry DOI: 10.7270/Q2TT4T17
					More data for this Ligand-Target Pair