BDBM332756 N-[6-[(3R)-3-(Pyridazin-3-ylamino)pyrrolidin-1-yl]pyridazin-3-yl]-2-[2-(trifluoromethyl)phenyl]acetamide::US10196382, Example 5::US10577354, Example 5
SMILES: FC(F)(F)c1ccccc1CC(=O)Nc1ccc(nn1)N1CC[C@H](C1)Nc1cccnn1
InChI Key: InChIKey=OTCWMVAEXPSBAB-OAHLLOKOSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM332756 (N-[6-[(3R)-3-(Pyridazin-3-ylamino)pyrrolidin-1-yl]...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 30.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Cancer Research Technology Limited US Patent | Assay Description A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t... | US Patent US10577354 (2020) BindingDB Entry DOI: 10.7270/Q2R49T4Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human)) | BDBM332756 (N-[6-[(3R)-3-(Pyridazin-3-ylamino)pyrrolidin-1-yl]...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 30.6 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca AB; Cancer Research Technology Limited US Patent | Assay Description GLS Enzyme Potency AssayA Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity ... | US Patent US10196382 (2019) BindingDB Entry DOI: 10.7270/Q2Q242BN | |||||||||||
More data for this Ligand-Target Pair |