BDBM333404 2-{[3-(4-Ethoxyfuro[3,2-c]pyridin-2-yl)imidazo[1,2-b]pyridazin-6-yl](methyl)amino}-1-phenylethanol::US9730929, Example 25

SMILES: CCOc1nccc2oc(cc12)-c1cnc2ccc(nn12)N(C)CC(O)c1ccccc1

InChI Key: InChIKey=VBNWAQKICGZVNT-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 333404   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM333404 (2-{[3-(4-Ethoxyfuro[3,2-c]pyridin-2-yl)imidazo[1,2...) Show SMILES CCOc1nccc2oc(cc12)-c1cnc2ccc(nn12)N(C)CC(O)c1ccccc1 |w:24.28| Show InChI InChI=1S/C24H23N5O3/c1-3-31-24-17-13-21(32-20(17)11-12-25-24)18-14-26-22-9-10-23(27-29(18)22)28(2)15-19(30)16-7-5-4-6-8-16/h4-14,19,30H,3,15H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
BAYER INTELLECTUAL PROPERTY GMBH US Patent					Assay Description A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...				US Patent US9730929 (2017) BindingDB Entry DOI: 10.7270/Q28S4S1H
					More data for this Ligand-Target Pair