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BDBM336260 US9744172, Compound UNC00000569A

SMILES: CCCCNc1ncc2c(nn(CC3CC[C@H](N)CC3)c2n1)-c1ccc(F)cc1

InChI Key: InChIKey=OGEBRHQLRGFBNV-OZEGIUPXSA-N

Data: 1 IC50

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 336260   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase Mer


(Homo sapiens (Human))		BDBM336260
PNG
(US9744172, Compound UNC00000569A)
Show SMILES CCCCNc1ncc2c(nn(CC3CC[C@H](N)CC3)c2n1)-c1ccc(F)cc1 |r,wD:16.16,(-8.57,-2.63,;-7.24,-1.86,;-5.91,-2.63,;-4.57,-1.86,;-3.24,-2.63,;-1.91,-1.86,;-1.91,-.32,;-.57,.45,;.76,-.32,;2.23,.16,;3.13,-1.09,;2.23,-2.33,;2.62,-3.82,;4.11,-4.22,;5.2,-3.13,;6.69,-3.53,;7.09,-5.02,;8.57,-5.42,;6,-6.11,;4.51,-5.71,;.76,-1.86,;-.57,-2.63,;2.62,1.64,;4.11,2.04,;4.51,3.53,;3.42,4.62,;3.82,6.11,;1.93,4.22,;1.54,2.73,)|
Show InChI InChI=1S/C22H29FN6/c1-2-3-12-25-22-26-13-19-20(16-6-8-17(23)9-7-16)28-29(21(19)27-22)14-15-4-10-18(24)11-5-15/h6-9,13,15,18H,2-5,10-12,14,24H2,1H3,(H,25,26,27)/t15?,18-
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US Patent
n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...

US Patent US9744172 (2017)


BindingDB Entry DOI: 10.7270/Q2PR7Z30
More data for this
Ligand-Target Pair