BDBM3363 5-{2-chloro-5-methylimidazo[1,5-a]pyridazin-7-yl}pentyl benzoate::Imidazopyridazine 15a

SMILES: Cc1nc(CCCCCOC(=O)c2ccccc2)n2nc(Cl)ccc12

InChI Key: InChIKey=VAQJZQNQAXFGQV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 3363   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HIV-1 Reverse Transcriptase (Human immunodeficiency virus type 1)	BDBM3363 (5-{2-chloro-5-methylimidazo[1,5-a]pyridazin-7-yl}p...) Show SMILES Cc1nc(CCCCCOC(=O)c2ccccc2)n2nc(Cl)ccc12 Show InChI InChI=1S/C19H20ClN3O2/c1-14-16-11-12-17(20)22-23(16)18(21-14)10-6-3-7-13-25-19(24)15-8-4-2-5-9-15/h2,4-5,8-9,11-12H,3,6-7,10,13H2,1H3	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	8.0	37
Glaxo Group Research Ltd.					Assay Description The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.				J Med Chem 36: 3784-94 (1993) Article DOI: 10.1021/jm00076a005 BindingDB Entry DOI: 10.7270/Q2PR7T57
					More data for this Ligand-Target Pair