BDBM337234 N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl]-2-hydroxy-2-(pyridin-3-yl)acetamide::US9745304, Example 3

SMILES: OC(C(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1cccnc1

InChI Key: InChIKey=FQFWDRRIGZELJC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 337234   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (Homo sapiens (Human))	BDBM337234 (N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...) Show SMILES OC(C(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1cccnc1 |w:1.0| Show InChI InChI=1S/C21H15N5O3/c27-20(14-5-3-9-22-11-14)21(28)24-18-7-8-19-23-12-15(26(19)25-18)17-10-13-4-1-2-6-16(13)29-17/h1-12,20,27H,(H,24,25,28)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9745304 (2017) BindingDB Entry DOI: 10.7270/Q2D79DHV
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (Homo sapiens (Human))	BDBM337234 (N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...) Show SMILES OC(C(=O)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1cccnc1 |w:1.0| Show InChI InChI=1S/C21H15N5O3/c27-20(14-5-3-9-22-11-14)21(28)24-18-7-8-19-23-12-15(26(19)25-18)17-10-13-4-1-2-6-16(13)29-17/h1-12,20,27H,(H,24,25,28)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9745304 (2017) BindingDB Entry DOI: 10.7270/Q2D79DHV
					More data for this Ligand-Target Pair