BDBM337240 N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl]-3-(pyridin-3-yl)propanamide::US9745304, Example 9

SMILES: O=C(CCc1cccnc1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1

InChI Key: InChIKey=DIMYYEALYLMAGB-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 337240   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (Homo sapiens (Human))	BDBM337240 (N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...) Show SMILES O=C(CCc1cccnc1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1 Show InChI InChI=1S/C22H17N5O2/c28-22(10-7-15-4-3-11-23-13-15)25-20-8-9-21-24-14-17(27(21)26-20)19-12-16-5-1-2-6-18(16)29-19/h1-6,8-9,11-14H,7,10H2,(H,25,26,28)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9745304 (2017) BindingDB Entry DOI: 10.7270/Q2D79DHV
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (Homo sapiens (Human))	BDBM337240 (N-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-...) Show SMILES O=C(CCc1cccnc1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1 Show InChI InChI=1S/C22H17N5O2/c28-22(10-7-15-4-3-11-23-13-15)25-20-8-9-21-24-14-17(27(21)26-20)19-12-16-5-1-2-6-18(16)29-19/h1-6,8-9,11-14H,7,10H2,(H,25,26,28)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9745304 (2017) BindingDB Entry DOI: 10.7270/Q2D79DHV
					More data for this Ligand-Target Pair