BDBM337242 (5S)-1-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6-yl]-5-(hydroxymethyl)-pyrrolidin-2-one::US9745304, Example 11

SMILES: OC[C@@H]1CCC(=O)N1c1ccc2ncc(-c3cc4ccccc4o3)n2n1

InChI Key: InChIKey=APAZAFAHWYCIQA-ZDUSSCGKSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 337242   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (Homo sapiens (Human))	BDBM337242 ((5S)-1-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridaz...) Show SMILES OC[C@@H]1CCC(=O)N1c1ccc2ncc(-c3cc4ccccc4o3)n2n1 |r| Show InChI InChI=1S/C19H16N4O3/c24-11-13-5-8-19(25)22(13)18-7-6-17-20-10-14(23(17)21-18)16-9-12-3-1-2-4-15(12)26-16/h1-4,6-7,9-10,13,24H,5,8,11H2/t13-/m0/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9745304 (2017) BindingDB Entry DOI: 10.7270/Q2D79DHV
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (Homo sapiens (Human))	BDBM337242 ((5S)-1-[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridaz...) Show SMILES OC[C@@H]1CCC(=O)N1c1ccc2ncc(-c3cc4ccccc4o3)n2n1 |r| Show InChI InChI=1S/C19H16N4O3/c24-11-13-5-8-19(25)22(13)18-7-6-17-20-10-14(23(17)21-18)16-9-12-3-1-2-4-15(12)26-16/h1-4,6-7,9-10,13,24H,5,8,11H2/t13-/m0/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...				US Patent US9745304 (2017) BindingDB Entry DOI: 10.7270/Q2D79DHV
					More data for this Ligand-Target Pair