BDBM337246 (2R)-2-hydroxy-N-[3-(4-methoxyfuro[3,2-c]pyridin-2-yl)imidazo[1,2-b]-pyridazin-6-yl]propanamide::US9745304, Example 15
SMILES: COc1nccc2oc(cc12)-c1cnc2ccc(NC(=O)[C@@H](C)O)nn12
InChI Key: InChIKey=PJWUSWRCXKIDCP-SECBINFHSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (Homo sapiens (Human)) | BDBM337246 ((2R)-2-hydroxy-N-[3-(4-methoxyfuro[3,2-c]pyridin-2...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (... | US Patent US9745304 (2017) BindingDB Entry DOI: 10.7270/Q2D79DHV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (Homo sapiens (Human)) | BDBM337246 ((2R)-2-hydroxy-N-[3-(4-methoxyfuro[3,2-c]pyridin-2...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
BAYER PHARMA AKTIENGESELLSCHAFT US Patent | Assay Description For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (... | US Patent US9745304 (2017) BindingDB Entry DOI: 10.7270/Q2D79DHV | |||||||||||
More data for this Ligand-Target Pair |