BDBM337271 8-hydroxy-3-(2-methylpyridin-4-yl)-5,6-dihydro-1H-pyrazolo[4,3-g]quinolin-7(8H)-one::US9745307, Example 8

SMILES: Cc1cc(ccn1)-c1n[nH]c2cc3n(O)c(=O)ccc3cc12

InChI Key: InChIKey=AEFAWOSWNRHSTP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 337271   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM337271 (8-hydroxy-3-(2-methylpyridin-4-yl)-5,6-dihydro-1H-...) Show SMILES Cc1cc(ccn1)-c1n[nH]c2cc3n(O)c(=O)ccc3cc12 Show InChI InChI=1S/C16H12N4O2/c1-9-6-11(4-5-17-9)16-12-7-10-2-3-15(21)20(22)14(10)8-13(12)18-19-16/h2-8,22H,1H3,(H,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...				US Patent US9745307 (2017) BindingDB Entry DOI: 10.7270/Q28G8NTK
					More data for this Ligand-Target Pair