BDBM337621 5-{2-Fluoro-4-[2-tetrahydro-2H- pyran-4-ylsulfonyl)-6- (trifluoromethyl)pyridin-3- yl]phenyl}pyrazin-2-amine::US9745328, Compound 906
SMILES: Nc1cnc(cn1)-c1ccc(cc1F)-c1ccc(nc1S(=O)(=O)C1CCOCC1)C(F)(F)F
InChI Key: InChIKey=SHTAMPJOMRLNGP-UHFFFAOYSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Flap endonuclease 1 (Homo sapiens (Human)) | BDBM337621 (5-{2-Fluoro-4-[2-tetrahydro-2H- pyran-4-ylsulfonyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma... | US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446 | |||||||||||
More data for this Ligand-Target Pair |