BDBM337998 US9751854, Compound I-174::US9802960, Compound I-174

SMILES: CN(C)c1ncc(cc1C(=O)N(C)c1ccc(F)cc1F)-c1ccnc(NC(C)=O)c1

InChI Key: InChIKey=ZMFRHJBEGJVWJH-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 337998   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 3-kinase catalytic subunit type 3 (Homo sapiens (Human))	BDBM337998 (US9751854, Compound I-174 | US9802960, Compound I-...) Show SMILES CN(C)c1ncc(cc1C(=O)N(C)c1ccc(F)cc1F)-c1ccnc(NC(C)=O)c1 Show InChI InChI=1S/C22H21F2N5O2/c1-13(30)27-20-10-14(7-8-25-20)15-9-17(21(26-12-15)28(2)3)22(31)29(4)19-6-5-16(23)11-18(19)24/h5-12H,1-4H3,(H,25,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. US Patent					Assay Description 100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...				US Patent US9802960 (2017) BindingDB Entry DOI: 10.7270/Q2D79DJ9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase catalytic subunit type 3 (Homo sapiens (Human))	BDBM337998 (US9751854, Compound I-174 | US9802960, Compound I-...) Show SMILES CN(C)c1ncc(cc1C(=O)N(C)c1ccc(F)cc1F)-c1ccnc(NC(C)=O)c1 Show InChI InChI=1S/C22H21F2N5O2/c1-13(30)27-20-10-14(7-8-25-20)15-9-17(21(26-12-15)28(2)3)22(31)29(4)19-6-5-16(23)11-18(19)24/h5-12H,1-4H3,(H,25,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Millennium Pharmaceuticals, Inc. US Patent					Assay Description 100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...				US Patent US9751854 (2017) BindingDB Entry DOI: 10.7270/Q2KS6TNJ
					More data for this Ligand-Target Pair