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SMILES: Cc1nc(CCCCCCC(=O)c2ccccc2)n2nc(ccc12)-n1ccnn1

InChI Key: InChIKey=WQYZLVLXRMCDBT-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 3389   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Gag-Pol polyprotein [588-1027]/[588-1147]


(Human immunodeficiency virus type 1)		BDBM3389
PNG
(7-[5-methyl-2-(1H-1,2,3-triazol-1-yl)imidazo[1,5-a...)
Show SMILES Cc1nc(CCCCCCC(=O)c2ccccc2)n2nc(ccc12)-n1ccnn1
Show InChI InChI=1S/C22H24N6O/c1-17-19-13-14-22(27-16-15-23-26-27)25-28(19)21(24-17)12-8-3-2-7-11-20(29)18-9-5-4-6-10-18/h4-6,9-10,13-16H,2-3,7-8,11-12H2,1H3
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n/an/a 640n/an/an/an/an/an/a



Glaxo Group Research Ltd.



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 36: 3784-94 (1993)


Article DOI: 10.1021/jm00076a005
BindingDB Entry DOI: 10.7270/Q2PR7T57
More data for this
Ligand-Target Pair