null

SMILES: COc1nc2ccc(cc2c(Cl)c1CN1CCC(O)(CC1)C(F)(F)F)C(O)(c1cncn1C)c1ccnc(c1)C(F)(F)F

InChI Key: InChIKey=DLFDVSBYPJENKR-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 339060   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM339060 (US10201546, Example 16 | US10201546, Example 182a) Show SMILES COc1nc2ccc(cc2c(Cl)c1CN1CCC(O)(CC1)C(F)(F)F)C(O)(c1cncn1C)c1ccnc(c1)C(F)(F)F Show InChI InChI=1S/C28H26ClF6N5O3/c1-39-15-36-13-22(39)26(42,17-5-8-37-21(12-17)27(30,31)32)16-3-4-20-18(11-16)23(29)19(24(38-20)43-2)14-40-9-6-25(41,7-10-40)28(33,34)35/h3-5,8,11-13,15,41-42H,6-7,9-10,14H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description ThermoFluor is a fluorescence based assay that estimates ligand binding affinities by measuring the effect of a ligand on protein thermal stability (...				US Patent US10201546 (2019) BindingDB Entry DOI: 10.7270/Q2F47R8C
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM339060 (US10201546, Example 16 | US10201546, Example 182a) Show SMILES COc1nc2ccc(cc2c(Cl)c1CN1CCC(O)(CC1)C(F)(F)F)C(O)(c1cncn1C)c1ccnc(c1)C(F)(F)F Show InChI InChI=1S/C28H26ClF6N5O3/c1-39-15-36-13-22(39)26(42,17-5-8-37-21(12-17)27(30,31)32)16-3-4-20-18(11-16)23(29)19(24(38-20)43-2)14-40-9-6-25(41,7-10-40)28(33,34)35/h3-5,8,11-13,15,41-42H,6-7,9-10,14H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description A reporter assay was used to test functional activity of RORγt modulatory compounds on transcriptional activation driven by the RORγt LBD. ...				US Patent US10201546 (2019) BindingDB Entry DOI: 10.7270/Q2F47R8C
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM339060 (US10201546, Example 16 | US10201546, Example 182a) Show SMILES COc1nc2ccc(cc2c(Cl)c1CN1CCC(O)(CC1)C(F)(F)F)C(O)(c1cncn1C)c1ccnc(c1)C(F)(F)F Show InChI InChI=1S/C28H26ClF6N5O3/c1-39-15-36-13-22(39)26(42,17-5-8-37-21(12-17)27(30,31)32)16-3-4-20-18(11-16)23(29)19(24(38-20)43-2)14-40-9-6-25(41,7-10-40)28(33,34)35/h3-5,8,11-13,15,41-42H,6-7,9-10,14H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description ThermoFluor is a fluorescence based assay that estimates ligand binding affinities by measuring the effect of a ligand on protein thermal stability (...				US Patent US10201546 (2019) BindingDB Entry DOI: 10.7270/Q2F47R8C
					More data for this Ligand-Target Pair
Nuclear receptor ROR-gamma (Homo sapiens (Human))	BDBM339060 (US10201546, Example 16 | US10201546, Example 182a) Show SMILES COc1nc2ccc(cc2c(Cl)c1CN1CCC(O)(CC1)C(F)(F)F)C(O)(c1cncn1C)c1ccnc(c1)C(F)(F)F Show InChI InChI=1S/C28H26ClF6N5O3/c1-39-15-36-13-22(39)26(42,17-5-8-37-21(12-17)27(30,31)32)16-3-4-20-18(11-16)23(29)19(24(38-20)43-2)14-40-9-6-25(41,7-10-40)28(33,34)35/h3-5,8,11-13,15,41-42H,6-7,9-10,14H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description A reporter assay was used to test functional activity of RORγt modulatory compounds on transcriptional activation driven by the RORγt LBD. ...				US Patent US10201546 (2019) BindingDB Entry DOI: 10.7270/Q2F47R8C
					More data for this Ligand-Target Pair