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SMILES: COc1cc(OC)c(F)c(c1)\N=c1/ccc2ncc(cc2n1CCNC(C)C)-c1cnn(C)c1

InChI Key: InChIKey=AZKUVSKMPUVICI-BGABXYSRSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 339830   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM339830 (US9757364, Compound 28) Show SMILES COc1cc(OC)c(F)c(c1)\N=c1/ccc2ncc(cc2n1CCNC(C)C)-c1cnn(C)c1 Show InChI InChI=1S/C25H29FN6O2/c1-16(2)27-8-9-32-22-10-17(18-14-29-31(3)15-18)13-28-20(22)6-7-24(32)30-21-11-19(33-4)12-23(34-5)25(21)26/h6-7,10-16,27H,8-9H2,1-5H3/b30-24+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.69	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LTD US Patent					Assay Description In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...				US Patent US9757364 (2017) BindingDB Entry DOI: 10.7270/Q2SB47VT
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 2 (Homo sapiens (Human))	BDBM339830 (US9757364, Compound 28) Show SMILES COc1cc(OC)c(F)c(c1)\N=c1/ccc2ncc(cc2n1CCNC(C)C)-c1cnn(C)c1 Show InChI InChI=1S/C25H29FN6O2/c1-16(2)27-8-9-32-22-10-17(18-14-29-31(3)15-18)13-28-20(22)6-7-24(32)30-21-11-19(33-4)12-23(34-5)25(21)26/h6-7,10-16,27H,8-9H2,1-5H3/b30-24+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.13	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LTD US Patent					Assay Description In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...				US Patent US9757364 (2017) BindingDB Entry DOI: 10.7270/Q2SB47VT
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM339830 (US9757364, Compound 28) Show SMILES COc1cc(OC)c(F)c(c1)\N=c1/ccc2ncc(cc2n1CCNC(C)C)-c1cnn(C)c1 Show InChI InChI=1S/C25H29FN6O2/c1-16(2)27-8-9-32-22-10-17(18-14-29-31(3)15-18)13-28-20(22)6-7-24(32)30-21-11-19(33-4)12-23(34-5)25(21)26/h6-7,10-16,27H,8-9H2,1-5H3/b30-24+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	45.7	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LTD US Patent					Assay Description In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...				US Patent US9757364 (2017) BindingDB Entry DOI: 10.7270/Q2SB47VT
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM339830 (US9757364, Compound 28) Show SMILES COc1cc(OC)c(F)c(c1)\N=c1/ccc2ncc(cc2n1CCNC(C)C)-c1cnn(C)c1 Show InChI InChI=1S/C25H29FN6O2/c1-16(2)27-8-9-32-22-10-17(18-14-29-31(3)15-18)13-28-20(22)6-7-24(32)30-21-11-19(33-4)12-23(34-5)25(21)26/h6-7,10-16,27H,8-9H2,1-5H3/b30-24+	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.61	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LTD US Patent					Assay Description In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...				US Patent US9757364 (2017) BindingDB Entry DOI: 10.7270/Q2SB47VT
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM339830 (US9757364, Compound 28) Show SMILES COc1cc(OC)c(F)c(c1)\N=c1/ccc2ncc(cc2n1CCNC(C)C)-c1cnn(C)c1 Show InChI InChI=1S/C25H29FN6O2/c1-16(2)27-8-9-32-22-10-17(18-14-29-31(3)15-18)13-28-20(22)6-7-24(32)30-21-11-19(33-4)12-23(34-5)25(21)26/h6-7,10-16,27H,8-9H2,1-5H3/b30-24+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.12	n/a	n/a	n/a	n/a	n/a	n/a
ASTEX THERAPEUTICS LTD US Patent					Assay Description In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...				US Patent US9757364 (2017) BindingDB Entry DOI: 10.7270/Q2SB47VT
					More data for this Ligand-Target Pair