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SMILES: CC(C)(C)S(=O)(=O)C[C@H](C1CC1)N1[C@@H]([C@H](O[C@](C)(Cc2ccc(cn2)C(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)c(F)c1

InChI Key: InChIKey=ILRYIEMVGUAAAV-OZLMZZSTSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 339934   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
E3 ubiquitin-protein ligase Mdm2 [1-188]


(Homo sapiens (Human))		BDBM339934
PNG
(US9758495, 7)
Show SMILES CC(C)(C)S(=O)(=O)C[C@H](C1CC1)N1[C@@H]([C@H](O[C@](C)(Cc2ccc(cn2)C(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C33H35Cl2FN2O6S/c1-32(2,3)45(42,43)18-27(19-8-9-19)38-28(20-11-13-25(35)26(36)15-20)29(21-6-5-7-23(34)14-21)44-33(4,31(38)41)16-24-12-10-22(17-37-24)30(39)40/h5-7,10-15,17,19,27-29H,8-9,16,18H2,1-4H3,(H,39,40)/t27-,28-,29-,33-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<0.100n/an/an/an/an/an/a



Amgen Inc.

US Patent


Assay Description
The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...

US Patent US9758495 (2017)


BindingDB Entry DOI: 10.7270/Q24M96NG
More data for this
Ligand-Target Pair