BDBM340172 (S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimidazo[1,5-a]pyrazin-1-yl)- N-(thiazol-2-yl)benzamide::US10239883, Example 101::US10934296, Example 101::US9758524, Example 101

SMILES: Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3nccs3)c12)[C@@H]1CCCN1C(=O)C=C

InChI Key: InChIKey=BQGRYJYLKCLQOX-INIZCTEOSA-N

Data: 15 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 340172   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM340172 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3nccs3)c12)[C@@H]1CCCN1C(=O)C=C |r| Show InChI InChI=1S/C23H21N7O2S/c1-2-17(31)29-11-3-4-16(29)21-27-18(19-20(24)25-9-12-30(19)21)14-5-7-15(8-6-14)22(32)28-23-26-10-13-33-23/h2,5-10,12-13,16H,1,3-4,11H2,(H2,24,25)(H,26,28,32)/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<10	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Btk enzyme (His-Btk (Millipore catalog #14-552), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM D...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340172 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3nccs3)c12)[C@@H]1CCCN1C(=O)C=C |r| Show InChI InChI=1S/C23H21N7O2S/c1-2-17(31)29-11-3-4-16(29)21-27-18(19-20(24)25-9-12-30(19)21)14-5-7-15(8-6-14)22(32)28-23-26-10-13-33-23/h2,5-10,12-13,16H,1,3-4,11H2,(H2,24,25)(H,26,28,32)/t16-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021)
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM340172 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3nccs3)c12)[C@@H]1CCCN1C(=O)C=C |r| Show InChI InChI=1S/C23H21N7O2S/c1-2-17(31)29-11-3-4-16(29)21-27-18(19-20(24)25-9-12-30(19)21)14-5-7-15(8-6-14)22(32)28-23-26-10-13-33-23/h2,5-10,12-13,16H,1,3-4,11H2,(H2,24,25)(H,26,28,32)/t16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Src enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Src enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Fyn (Homo sapiens (Human))	BDBM340172 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3nccs3)c12)[C@@H]1CCCN1C(=O)C=C |r| Show InChI InChI=1S/C23H21N7O2S/c1-2-17(31)29-11-3-4-16(29)21-27-18(19-20(24)25-9-12-30(19)21)14-5-7-15(8-6-14)22(32)28-23-26-10-13-33-23/h2,5-10,12-13,16H,1,3-4,11H2,(H2,24,25)(H,26,28,32)/t16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description FynT enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.FynT enzyme ...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lyn (Homo sapiens (Human))	BDBM340172 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3nccs3)c12)[C@@H]1CCCN1C(=O)C=C |r| Show InChI InChI=1S/C23H21N7O2S/c1-2-17(31)29-11-3-4-16(29)21-27-18(19-20(24)25-9-12-30(19)21)14-5-7-15(8-6-14)22(32)28-23-26-10-13-33-23/h2,5-10,12-13,16H,1,3-4,11H2,(H2,24,25)(H,26,28,32)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lyn enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lyn enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM340172 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3nccs3)c12)[C@@H]1CCCN1C(=O)C=C |r| Show InChI InChI=1S/C23H21N7O2S/c1-2-17(31)29-11-3-4-16(29)21-27-18(19-20(24)25-9-12-30(19)21)14-5-7-15(8-6-14)22(32)28-23-26-10-13-33-23/h2,5-10,12-13,16H,1,3-4,11H2,(H2,24,25)(H,26,28,32)/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<10	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Btk enzyme (His-Btk (Millipore catalog #14-552), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM D...				J Med Chem 48: 6169-73 (2005) BindingDB Entry DOI: 10.7270/Q20R9RQ4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340172 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3nccs3)c12)[C@@H]1CCCN1C(=O)C=C |r| Show InChI InChI=1S/C23H21N7O2S/c1-2-17(31)29-11-3-4-16(29)21-27-18(19-20(24)25-9-12-30(19)21)14-5-7-15(8-6-14)22(32)28-23-26-10-13-33-23/h2,5-10,12-13,16H,1,3-4,11H2,(H2,24,25)(H,26,28,32)/t16-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ...				J Med Chem 48: 6169-73 (2005) BindingDB Entry DOI: 10.7270/Q20R9RQ4
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM340172 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3nccs3)c12)[C@@H]1CCCN1C(=O)C=C |r| Show InChI InChI=1S/C23H21N7O2S/c1-2-17(31)29-11-3-4-16(29)21-27-18(19-20(24)25-9-12-30(19)21)14-5-7-15(8-6-14)22(32)28-23-26-10-13-33-23/h2,5-10,12-13,16H,1,3-4,11H2,(H2,24,25)(H,26,28,32)/t16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Src enzyme (Millipore catalog #14-326), is diluted to 0.8 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ...				J Med Chem 48: 6169-73 (2005) BindingDB Entry DOI: 10.7270/Q20R9RQ4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Fyn (Homo sapiens (Human))	BDBM340172 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3nccs3)c12)[C@@H]1CCCN1C(=O)C=C |r| Show InChI InChI=1S/C23H21N7O2S/c1-2-17(31)29-11-3-4-16(29)21-27-18(19-20(24)25-9-12-30(19)21)14-5-7-15(8-6-14)22(32)28-23-26-10-13-33-23/h2,5-10,12-13,16H,1,3-4,11H2,(H2,24,25)(H,26,28,32)/t16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description FynT enzyme (Biomol catalog #SE-287), is diluted to 0.5 μg/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2...				J Med Chem 48: 6169-73 (2005) BindingDB Entry DOI: 10.7270/Q20R9RQ4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lyn (Homo sapiens (Human))	BDBM340172 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3nccs3)c12)[C@@H]1CCCN1C(=O)C=C |r| Show InChI InChI=1S/C23H21N7O2S/c1-2-17(31)29-11-3-4-16(29)21-27-18(19-20(24)25-9-12-30(19)21)14-5-7-15(8-6-14)22(32)28-23-26-10-13-33-23/h2,5-10,12-13,16H,1,3-4,11H2,(H2,24,25)(H,26,28,32)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Lyn enzyme (Millipore catalog #14-510), is diluted to 250 mU/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM...				J Med Chem 48: 6169-73 (2005) BindingDB Entry DOI: 10.7270/Q20R9RQ4
					More data for this Ligand-Target Pair
Protein cereblon/Tyrosine-protein kinase SRC (Homo sapiens (Human))	BDBM340172 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3nccs3)c12)[C@@H]1CCCN1C(=O)C=C |r| Show InChI InChI=1S/C23H21N7O2S/c1-2-17(31)29-11-3-4-16(29)21-27-18(19-20(24)25-9-12-30(19)21)14-5-7-15(8-6-14)22(32)28-23-26-10-13-33-23/h2,5-10,12-13,16H,1,3-4,11H2,(H2,24,25)(H,26,28,32)/t16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Src enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Src enzyme (M...				US Patent US10934296 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Fyn (Homo sapiens (Human))	BDBM340172 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3nccs3)c12)[C@@H]1CCCN1C(=O)C=C |r| Show InChI InChI=1S/C23H21N7O2S/c1-2-17(31)29-11-3-4-16(29)21-27-18(19-20(24)25-9-12-30(19)21)14-5-7-15(8-6-14)22(32)28-23-26-10-13-33-23/h2,5-10,12-13,16H,1,3-4,11H2,(H2,24,25)(H,26,28,32)/t16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description FynT enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.FynT enzyme ...				US Patent US10934296 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lyn (Homo sapiens (Human))	BDBM340172 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3nccs3)c12)[C@@H]1CCCN1C(=O)C=C |r| Show InChI InChI=1S/C23H21N7O2S/c1-2-17(31)29-11-3-4-16(29)21-27-18(19-20(24)25-9-12-30(19)21)14-5-7-15(8-6-14)22(32)28-23-26-10-13-33-23/h2,5-10,12-13,16H,1,3-4,11H2,(H2,24,25)(H,26,28,32)/t16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lyn enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lyn enzyme (M...				US Patent US10934296 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM340172 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3nccs3)c12)[C@@H]1CCCN1C(=O)C=C |r| Show InChI InChI=1S/C23H21N7O2S/c1-2-17(31)29-11-3-4-16(29)21-27-18(19-20(24)25-9-12-30(19)21)14-5-7-15(8-6-14)22(32)28-23-26-10-13-33-23/h2,5-10,12-13,16H,1,3-4,11H2,(H2,24,25)(H,26,28,32)/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<10	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Btk enzyme (H...				US Patent US10934296 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340172 ((S)-4-(3-(1-acryloylpyrrolidin-2-yl)- 8-aminoimida...) Show SMILES Nc1nccn2c(nc(-c3ccc(cc3)C(=O)Nc3nccs3)c12)[C@@H]1CCCN1C(=O)C=C |r| Show InChI InChI=1S/C23H21N7O2S/c1-2-17(31)29-11-3-4-16(29)21-27-18(19-20(24)25-9-12-30(19)21)14-5-7-15(8-6-14)22(32)28-23-26-10-13-33-23/h2,5-10,12-13,16H,1,3-4,11H2,(H2,24,25)(H,26,28,32)/t16-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair