BDBM340504 US9763922, Example 35

SMILES: CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1cn(C)nc1C(C)(F)F)nn2C

InChI Key: InChIKey=WGQUGZXNFFIKIJ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 340504   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM340504 (US9763922, Example 35) Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1cn(C)nc1C(C)(F)F)nn2C Show InChI InChI=1S/C21H24F2N6O/c1-13(30)29-9-8-18-17(12-29)20(26-28(18)4)24-15-7-5-6-14(10-15)16-11-27(3)25-19(16)21(2,22)23/h5-7,10-11H,8-9,12H2,1-4H3,(H,24,26)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.98E+3	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...				US Patent US9763922 (2017) BindingDB Entry DOI: 10.7270/Q23N25G6
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM340504 (US9763922, Example 35) Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1cn(C)nc1C(C)(F)F)nn2C Show InChI InChI=1S/C21H24F2N6O/c1-13(30)29-9-8-18-17(12-29)20(26-28(18)4)24-15-7-5-6-14(10-15)16-11-27(3)25-19(16)21(2,22)23/h5-7,10-11H,8-9,12H2,1-4H3,(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...				US Patent US9763922 (2017) BindingDB Entry DOI: 10.7270/Q23N25G6
					More data for this Ligand-Target Pair