BDBM340977 N-(4-Hydroxyphenyl)-N-(4-methylphenyl)-1-(6-{[(3S)-3-[(4-methylpiperazin-1-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}-1,3-benzodioxol-5-yl)-1H-indole-3-carboxamide::US9765056, Example 32

SMILES: CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccc(C)cc3)c3ccc(O)cc3)c3ccccc23)CC1

InChI Key: InChIKey=WGQBROCOTZOUCG-DHUJRADRSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340977   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM340977 (N-(4-Hydroxyphenyl)-N-(4-methylphenyl)-1-(6-{[(3S)...) Show SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccc(C)cc3)c3ccc(O)cc3)c3ccccc23)CC1 Show InChI InChI=1S/C45H43N5O5/c1-30-11-13-33(14-12-30)50(34-15-17-36(51)18-16-34)45(53)39-28-49(40-10-6-5-9-37(39)40)41-25-43-42(54-29-55-43)24-38(41)44(52)48-26-32-8-4-3-7-31(32)23-35(48)27-47-21-19-46(2)20-22-47/h3-18,24-25,28,35,51H,19-23,26-27,29H2,1-2H3/t35-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...				US Patent US9765056 (2017) BindingDB Entry DOI: 10.7270/Q2T72KJF
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