BDBM341255 (S)-2,4-diamino-6-((1-(3-(3-fluorophenyl)-4-oxo-5-((2-(pyrrolidin-1-yl)ethyl)sulfonyl)-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile ::US9765060, Compound 82
SMILES: C[C@H](Nc1nc(N)nc(N)c1C#N)c1nc2cccc(c2c(=O)n1-c1cccc(F)c1)S(=O)(=O)CCN1CCCC1
InChI Key: InChIKey=LCSYWUOYYCCHSB-INIZCTEOSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM341255 ((S)-2,4-diamino-6-((1-(3-(3-fluorophenyl)-4-oxo-5-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
GILEAD SCIENCES, INC. US Patent | Assay Description TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks... | US Patent US9765060 (2017) BindingDB Entry DOI: 10.7270/Q2DZ0BDH | |||||||||||
More data for this Ligand-Target Pair |