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SMILES: Nc1nc(N)c(C#N)c(n1)N1CCC[C@H]1c1nc2cccc(C#N)c2c(=O)n1-c1ccccc1

InChI Key: InChIKey=HXUKDGSMTPBFQB-SFHVURJKSA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 341262   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))		BDBM341262
PNG
((S)-2-(1-(2,6-diamino-5-cyanopyrimidin-4-yl)pyrrol...)
Show SMILES Nc1nc(N)c(C#N)c(n1)N1CCC[C@H]1c1nc2cccc(C#N)c2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C24H19N9O/c25-12-14-6-4-9-17-19(14)23(34)33(15-7-2-1-3-8-15)22(29-17)18-10-5-11-32(18)21-16(13-26)20(27)30-24(28)31-21/h1-4,6-9,18H,5,10-11H2,(H4,27,28,30,31)/t18-/m0/s1
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US Patent
n/an/a 2n/an/an/an/an/an/a



GILEAD SCIENCES, INC.

US Patent


Assay Description
TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks...

US Patent US9765060 (2017)


BindingDB Entry DOI: 10.7270/Q2DZ0BDH
More data for this
Ligand-Target Pair