BDBM341270 (S)-2-(1-((2-amino-5-iodo-6-methylpyrimidin-4-yl)amino)ethyl)-5-chloro-3-phenylquinazolin-4(3H)-one ::US9765060, Compound 97
SMILES: C[C@H](Nc1nc(N)nc(C)c1I)c1nc2cccc(Cl)c2c(=O)n1-c1ccccc1
InChI Key: InChIKey=TXJHXFSNTZWCEU-LBPRGKRZSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM341270 ((S)-2-(1-((2-amino-5-iodo-6-methylpyrimidin-4-yl)a...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
GILEAD SCIENCES, INC. US Patent | Assay Description TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIP3 for binding to the GRP-1 plecks... | US Patent US9765060 (2017) BindingDB Entry DOI: 10.7270/Q2DZ0BDH | |||||||||||
More data for this Ligand-Target Pair |