null

SMILES: Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)c1nc(C2CC2)c([nH]1)-c1ccccc1

InChI Key: InChIKey=GNFVLYBVNRWPBG-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 342163   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit [D816V] (Homo sapiens (Human))	BDBM342163 (4-[4-(4-cyclopropyl-5-phenyl-1H- imidazol-2-yl)-1-...) Show SMILES Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)c1nc(C2CC2)c([nH]1)-c1ccccc1 Show InChI InChI=1S/C29H27FN6/c30-22-10-8-18(9-11-22)24-16-23-28(33-24)31-17-32-29(23)36-14-12-21(13-15-36)27-34-25(19-4-2-1-3-5-19)26(35-27)20-6-7-20/h1-5,8-11,16-17,20-21H,6-7,12-15H2,(H,34,35)(H,31,32,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM342163 (4-[4-(4-cyclopropyl-5-phenyl-1H- imidazol-2-yl)-1-...) Show SMILES Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)N1CCC(CC1)c1nc(C2CC2)c([nH]1)-c1ccccc1 Show InChI InChI=1S/C29H27FN6/c30-22-10-8-18(9-11-22)24-16-23-28(33-24)31-17-32-29(23)36-14-12-21(13-15-36)27-34-25(19-4-2-1-3-5-19)26(35-27)20-6-7-20/h1-5,8-11,16-17,20-21H,6-7,12-15H2,(H,34,35)(H,31,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Plexxikon Inc. US Patent					Assay Description Assays for biochemical cell-based activity of c-kit kinase are known in the art, for example, as described in U.S. Pat. Nos. 7,498,342 and 7,846,941,...				US Patent US9771369 (2017) BindingDB Entry DOI: 10.7270/Q24J0H7Q
					More data for this Ligand-Target Pair