BDBM342428 N-(2-((4aR,8aR)-2-amino-6,6-dimethyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]oxazin-8a(8H)-yl)thiazol-4-yl)-5-(difluoromethoxy)-3-methylpicolinamide ::US9771379, Example 9

SMILES: Cc1cc(OC(F)F)cnc1C(=O)Nc1csc(n1)[C@]12COC(C)(C)C[C@H]1COC(N)=N2

InChI Key: InChIKey=MGUXFWJIHHQFOB-YBTHPKLGSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 342428   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 1 (Homo sapiens (Human))	BDBM342428 (N-(2-((4aR,8aR)-2-amino-6,6-dimethyl-4,4a,5,6-tetr...) Show SMILES Cc1cc(OC(F)F)cnc1C(=O)Nc1csc(n1)[C@]12COC(C)(C)C[C@H]1COC(N)=N2 |r,c:33| Show InChI InChI=1S/C20H23F2N5O4S/c1-10-4-12(31-17(21)22)6-24-14(10)15(28)25-13-8-32-16(26-13)20-9-30-19(2,3)5-11(20)7-29-18(23)27-20/h4,6,8,11,17H,5,7,9H2,1-3H3,(H2,23,27)(H,25,28)/t11-,20-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	475	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...				US Patent US9771379 (2017) BindingDB Entry DOI: 10.7270/Q2R78HC1
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