BDBM343944 1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((4-(3-methyl-3H-imidazo[4,5-b]pyridin-5-yl)pyridin-2-yl)amino)propan-2-ol::US9777008, Compound 238
SMILES: Cn1cnc2ccc(nc12)-c1ccnc(NCC(O)CN2CCc3ccccc3C2)c1
InChI Key: InChIKey=KDJMIAKLQTYCGG-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PRMT5/MEP50 Enzyme (Homo sapiens (Human)) | BDBM343944 (1-(3,4-dihydroisoquinolin-2(1H)-yl)-3-((4-(3-methy...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme, Inc. US Patent | Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use.... | US Patent US9777008 (2017) BindingDB Entry DOI: 10.7270/Q26975QQ | |||||||||||
More data for this Ligand-Target Pair |