BDBM343947 US9777008, Compound 241

SMILES: OC(CNc1cc(ccn1)-c1ccc2ncn(C3CCNCC3)c2c1)CN1CCc2ccccc2C1

InChI Key: InChIKey=LZULXYOPMJLNKF-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 343947   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
PRMT5/MEP50 Enzyme (Homo sapiens (Human))	BDBM343947 (US9777008, Compound 241) Show SMILES OC(CNc1cc(ccn1)-c1ccc2ncn(C3CCNCC3)c2c1)CN1CCc2ccccc2C1 Show InChI InChI=1S/C29H34N6O/c36-26(19-34-14-10-21-3-1-2-4-24(21)18-34)17-32-29-16-23(7-13-31-29)22-5-6-27-28(15-22)35(20-33-27)25-8-11-30-12-9-25/h1-7,13,15-16,20,25-26,30,36H,8-12,14,17-19H2,(H,31,32)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....				US Patent US9777008 (2017) BindingDB Entry DOI: 10.7270/Q26975QQ
					More data for this Ligand-Target Pair