BDBM344217 N-[6-(4-acetylpiperazin-1-yl)-2-ethoxypyridin-3-yl]-4′-oxo-4′,7′-dihydro-5′H-spiro[cyclobutane-1,6′-furo[3,2-c]pyridine]-3′-carboxamide::US9777020, Example 111

SMILES: CCOc1nc(ccc1NC(=O)c1coc2CC3(CCC3)NC(=O)c12)N1CCN(CC1)C(C)=O

InChI Key: InChIKey=IUDXHZMYWRINGG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 344217   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM344217 (N-[6-(4-acetylpiperazin-1-yl)-2-ethoxypyridin-3-yl...) Show SMILES CCOc1nc(ccc1NC(=O)c1coc2CC3(CCC3)NC(=O)c12)N1CCN(CC1)C(C)=O Show InChI InChI=1S/C24H29N5O5/c1-3-33-23-17(5-6-19(26-23)29-11-9-28(10-12-29)15(2)30)25-21(31)16-14-34-18-13-24(7-4-8-24)27-22(32)20(16)18/h5-6,14H,3-4,7-13H2,1-2H3,(H,25,31)(H,27,32)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent									US Patent US9777020 (2017) BindingDB Entry DOI: 10.7270/Q2T155R7
					More data for this Ligand-Target Pair