BDBM346512 US10202378, Example 116::[2-(trifluoromethyl)phenyl]methyl4-(3-hydroxy-3-methyl-but-1-ynyl)-2,6-dimethyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-3-carboxylate

SMILES: Cc1[nH]c2c(c1C(=O)OCc1ccccc1C(F)(F)F)c(cn(C)c2=O)C#CC(C)(C)O

InChI Key: InChIKey=RAJGCIKQGOENJW-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 346512   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TAF1-BD1 (aa 1381-1497) (Homo sapiens (human))	BDBM346512 (US10202378, Example 116 | [2-(trifluoromethyl)phen...) Show SMILES Cc1[nH]c2c(c1C(=O)OCc1ccccc1C(F)(F)F)c(cn(C)c2=O)C#CC(C)(C)O Show InChI InChI=1S/C23H21F3N2O4/c1-13-17(21(30)32-12-15-7-5-6-8-16(15)23(24,25)26)18-14(9-10-22(2,3)31)11-28(4)20(29)19(18)27-13/h5-8,11,27,31H,12H2,1-4H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	105	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description His/Flag epitope tagged TAF1-BD11381-1497 was cloned, expressed, and purified to homogeneity. TAF1-BD binding and inhibition was assessed by monitori...				US Patent US10202378 (2019) BindingDB Entry DOI: 10.7270/Q22B9149
					More data for this Ligand-Target Pair
TAF1-BD2 (aa 1504-1635) (Homo sapiens (Human))	BDBM346512 (US10202378, Example 116 | [2-(trifluoromethyl)phen...) Show SMILES Cc1[nH]c2c(c1C(=O)OCc1ccccc1C(F)(F)F)c(cn(C)c2=O)C#CC(C)(C)O Show InChI InChI=1S/C23H21F3N2O4/c1-13-17(21(30)32-12-15-7-5-6-8-16(15)23(24,25)26)18-14(9-10-22(2,3)31)11-28(4)20(29)19(18)27-13/h5-8,11,27,31H,12H2,1-4H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	27.7	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC. US Patent					Assay Description His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...				US Patent US10202378 (2019) BindingDB Entry DOI: 10.7270/Q22B9149
					More data for this Ligand-Target Pair