BDBM347069 US10202390, Example 24

SMILES: CC(C)(O)CCc1cn(nn1)-c1cnc(cc1NC1CC(F)(F)C1)-c1cnn2cc(cnc12)C#N

InChI Key: InChIKey=FRYFNOMIOVBKEM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 347069   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
G protein-activated inward rectifier potassium channel 4 (Homo sapiens (Human))	BDBM347069 (US10202390, Example 24) Show SMILES CC(C)(O)CCc1cn(nn1)-c1cnc(cc1NC1CC(F)(F)C1)-c1cnn2cc(cnc12)C#N Show InChI InChI=1S/C23H23F2N9O/c1-22(2,35)4-3-15-13-33(32-31-15)20-11-27-18(5-19(20)30-16-6-23(24,25)7-16)17-10-29-34-12-14(8-26)9-28-21(17)34/h5,9-13,16,35H,3-4,6-7H2,1-2H3,(H,27,30)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description TBD				US Patent US10202390 (2019) BindingDB Entry DOI: 10.7270/Q28W3GDC
					More data for this Ligand-Target Pair