BDBM347574 N,N-Dimethyl-4-({3-[2-(trifluoromethoxy)phenyl]piperidin-1-yl}carbonyl)pyridin-2-amine::US9790201, 60

SMILES: CN(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccccc1OC(F)(F)F

InChI Key: InChIKey=YUZUBJYYIXVUEU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 347574   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prokineticin receptor 1 (Homo sapiens (Human))	BDBM347574 (N,N-Dimethyl-4-({3-[2-(trifluoromethoxy)phenyl]pip...) Show SMILES CN(C)c1cc(ccn1)C(=O)N1CCCC(C1)c1ccccc1OC(F)(F)F Show InChI InChI=1S/C20H22F3N3O2/c1-25(2)18-12-14(9-10-24-18)19(27)26-11-5-6-15(13-26)16-7-3-4-8-17(16)28-20(21,22)23/h3-4,7-10,12,15H,5-6,11,13H2,1-2H3	MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited US Patent					Assay Description Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...				US Patent US9790201 (2017) BindingDB Entry DOI: 10.7270/Q2377BVZ
					More data for this Ligand-Target Pair