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SMILES: Cn1cc(c(n1)-c1ccc(cc1)C#Cc1cnc2ccccc2n1)-c1ccncc1

InChI Key: InChIKey=HEIFBGABZKSNHR-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 347648   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM347648
PNG
(2-[2-[4-[1-methyl-4-(4-pyridyl)pyrazol-3-yl]phenyl...)
Show SMILES Cn1cc(c(n1)-c1ccc(cc1)C#Cc1cnc2ccccc2n1)-c1ccncc1
Show InChI InChI=1S/C25H17N5/c1-30-17-22(19-12-14-26-15-13-19)25(29-30)20-9-6-18(7-10-20)8-11-21-16-27-23-4-2-3-5-24(23)28-21/h2-7,9-10,12-17H,1H3
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MMDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...

US Patent US9790203 (2017)


BindingDB Entry DOI: 10.7270/Q2ZG6VD4
More data for this
Ligand-Target Pair