BDBM347650 3-methoxy-2-[2-[4-[1-methyl-4-(4-pyridyl)pyrazol-3-yl]phenyl]ethynyl]pyridine::US9790203, Example 21

SMILES: COc1cccnc1C#Cc1ccc(cc1)-c1nn(C)cc1-c1ccncc1

InChI Key: InChIKey=HYDAVUZUYOPBQR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 347650   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM347650 (3-methoxy-2-[2-[4-[1-methyl-4-(4-pyridyl)pyrazol-3...) Show SMILES COc1cccnc1C#Cc1ccc(cc1)-c1nn(C)cc1-c1ccncc1 Show InChI InChI=1S/C23H18N4O/c1-27-16-20(18-11-14-24-15-12-18)23(26-27)19-8-5-17(6-9-19)7-10-21-22(28-2)4-3-13-25-21/h3-6,8-9,11-16H,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG US Patent					Assay Description The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...				US Patent US9790203 (2017) BindingDB Entry DOI: 10.7270/Q2ZG6VD4
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