BDBM347682 N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(((cis)-4-(dimethylamino)cyclohexyl)(ethyl)amino)-4-methylthiophene-3-carboxamide (Example 7) and N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(((trans)-4-(dimethylamino)cyclohexyl)(ethyl)amino)-4-methylthiophene-3-carboxamide (Example 8)::US9790212, Example 7::US9790212, Example 8
SMILES: CCN(C1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C
InChI Key:
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PRC2 complex (Homo sapiens (Human)) | BDBM347682 (N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED US Patent | Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com... | US Patent US9790212 (2017) BindingDB Entry DOI: 10.7270/Q2PZ5BZ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRC2 complex (Homo sapiens (Human)) | BDBM347682 (N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED US Patent | Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com... | US Patent US9790212 (2017) BindingDB Entry DOI: 10.7270/Q2PZ5BZ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRC2 complex (Homo sapiens (Human)) | BDBM347682 (N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED US Patent | Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com... | US Patent US9790212 (2017) BindingDB Entry DOI: 10.7270/Q2PZ5BZ2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PRC2 complex (Homo sapiens (Human)) | BDBM347682 (N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED US Patent | Assay Description Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com... | US Patent US9790212 (2017) BindingDB Entry DOI: 10.7270/Q2PZ5BZ2 | |||||||||||
More data for this Ligand-Target Pair |