BDBM34786 3-(4-methylphenyl)-2-phenyl-1,2,4-thiadiazol-2-ium-5-amine;bromide::MLS000722022::SMR000236708::[2-phenyl-3-(p-tolyl)-1,2,4-thiadiazol-2-ium-5-yl]amine;bromide::cid_12005893
SMILES: Cc1ccc(cc1)-c1nc(N)s[n+]1-c1ccccc1
InChI Key: InChIKey=NKSMZDXKRWEVEK-UHFFFAOYSA-O
Data: 11 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MPI protein (Homo sapiens (Human)) | BDBM34786 (3-(4-methylphenyl)-2-phenyl-1,2,4-thiadiazol-2-ium...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 4.91E+3 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description The purpose of this assay is to identify non-competititve inhibitors of human PMI. This is accomplished by using a G6PD- NADPH-coupled assay. In the ... | PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2CF9NFM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
neutrophil cytosolic factor 1 (Homo sapiens (Human)) | BDBM34786 (3-(4-methylphenyl)-2-phenyl-1,2,4-thiadiazol-2-ium...) | PDB MMDB Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 4.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Molecular Libraries Screening Center Curated by PubChem BioAssay | Assay Description NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Susan Smith, Emory Univers... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2M90723 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucose 6-phosphate dehydrogenase (G6PD) (Homo sapiens (Human)) | BDBM34786 (3-(4-methylphenyl)-2-phenyl-1,2,4-thiadiazol-2-ium...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 2.72E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA... | PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q2V12389 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase (Plasmodium falciparum 3D7) | BDBM34786 (3-(4-methylphenyl)-2-phenyl-1,2,4-thiadiazol-2-ium...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 9.13E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA... | PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q2ZS2TZG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase (Plasmodium falciparum 3D7) | BDBM34786 (3-(4-methylphenyl)-2-phenyl-1,2,4-thiadiazol-2-ium...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 6.03E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA... | PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q27H1H3W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone acetyltransferase GCN5 (Saccharomyces cerevisiae S288c) | BDBM34786 (3-(4-methylphenyl)-2-phenyl-1,2,4-thiadiazol-2-ium...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Clinic College of Medicine Curated by ChEMBL | Assay Description Inhibition of yeast histone acetyltransferase Gcn5-Ada2-Ada3 complex using tetramer and [3H]-acetyl-CoA assessed as acetate incorporation after 30 mi... | J Med Chem 58: 2091-113 (2015) Article DOI: 10.1021/jm5019093 BindingDB Entry DOI: 10.7270/Q26M38J9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone acetyltransferase GCN5 (Saccharomyces cerevisiae S288c) | BDBM34786 (3-(4-methylphenyl)-2-phenyl-1,2,4-thiadiazol-2-ium...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Clinic College of Medicine Curated by ChEMBL | Assay Description Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using Asf1-dH3-H4 as substrate assessed as coenz... | J Med Chem 58: 2091-113 (2015) Article DOI: 10.1021/jm5019093 BindingDB Entry DOI: 10.7270/Q26M38J9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone acetyltransferase GCN5 (Saccharomyces cerevisiae S288c) | BDBM34786 (3-(4-methylphenyl)-2-phenyl-1,2,4-thiadiazol-2-ium...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Clinic College of Medicine Curated by ChEMBL | Assay Description Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using Asf1-dH3-H4 as substrate assessed as coenz... | J Med Chem 58: 2091-113 (2015) Article DOI: 10.1021/jm5019093 BindingDB Entry DOI: 10.7270/Q26M38J9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone acetyltransferase GCN5 (Saccharomyces cerevisiae S288c) | BDBM34786 (3-(4-methylphenyl)-2-phenyl-1,2,4-thiadiazol-2-ium...) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 640 | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Clinic College of Medicine Curated by ChEMBL | Assay Description Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using [3H]-acetyl-CoA assessed as acetate incorp... | J Med Chem 58: 2091-113 (2015) Article DOI: 10.1021/jm5019093 BindingDB Entry DOI: 10.7270/Q26M38J9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone acetyltransferase p300 (Homo sapiens (Human)) | BDBM34786 (3-(4-methylphenyl)-2-phenyl-1,2,4-thiadiazol-2-ium...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Mayo Clinic College of Medicine Curated by ChEMBL | Assay Description Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation... | J Med Chem 58: 2091-113 (2015) Article DOI: 10.1021/jm5019093 BindingDB Entry DOI: 10.7270/Q26M38J9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase (Plasmodium falciparum 3D7) | BDBM34786 (3-(4-methylphenyl)-2-phenyl-1,2,4-thiadiazol-2-ium...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | >8.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego CA... | PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q23T9FQ1 | |||||||||||
More data for this Ligand-Target Pair |